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Stenosis Indicators Applied to Patient-Specific Renal Arteries without and with Stenosis
KTH, School of Engineering Sciences (SCI), Centres, BioMEx. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. Linköping Univ Hosp, Dept Radiol, SE-58185 Linköping, Sweden.
KTH, School of Engineering Sciences (SCI), Centres, BioMEx. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW.ORCID iD: 0000-0002-6881-2094
KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, School of Engineering Sciences (SCI), Centres, BioMEx.ORCID iD: 0000-0001-9976-8316
2019 (English)In: FLUIDS, ISSN 2311-5521, Vol. 4, no 1, article id 26Article in journal (Refereed) Published
Abstract [en]

Pulsatile flow in the abdominal aorta and the renal arteries of three patients was studied numerically. Two of the patients had renal artery stenosis. The aim of the study was to assess the use of four types of indicators for determining the risk of new stenosis after revascularization of the affected arteries. The four indicators considered include the time averaged wall shear stress (TAWSS), the oscillatory shear index (OSI), the relative reference time (RRT) and a power law model based in platelet activation modeling but applied to the endothelium, named endothelium activation indicator (EAI). The results show that the indicators can detect the existing stenosis but are less successful in the revascularized cases. The TAWSS and, more clearly, the EAI approach seem to be better in predicting the risk for stenosis relapse at the original location and close to the post-stenotic dilatation. The shortcomings of the respective indicators are discussed along with potential improvements to endothelial activation modeling and its use as an indicator for risks of restenosis.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 4, no 1, article id 26
Keywords [en]
renal artery stenosis, blood flow simulation, atherosclerosis, reconstructed arteries, stenosis indicators
National Category
Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:kth:diva-251364DOI: 10.3390/fluids4010026ISI: 000464457900001Scopus ID: 2-s2.0-85063386762OAI: oai:DiVA.org:kth-251364DiVA, id: diva2:1315402
Note

QC 20190513

Available from: 2019-05-13 Created: 2019-05-13 Last updated: 2019-05-23Bibliographically approved

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Berg, NiclasPrahl Wittberg, Lisa

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