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A new model for diffuse brain injury by rotational acceleration: I model, gross appearance, and astrocytosis
KTH, School of Engineering Sciences (SCI), Mechanics, Biomechanics. Chalmers University of Technology. (Biomechanics)ORCID iD: 0000-0001-5417-5939
2001 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 18, no 3, p. 247-257Article in journal (Refereed) Published
Abstract [en]

Rapid head rotation is a major cause of brain damage in automobile crashes and falls. This report details a new model for rotational acceleration about the center of mass of the rabbit head. This allows the study of brain injury without translational acceleration of the head. Impact from a pneumatic cylinder was transferred to the skull surface to cause a half-sine peak acceleration of 2.1 × 105 rad/s2 and 0.96-ms pulse duration. Extensive subarachnoid hemorrhages and small focal bleedings were observed in the brain tissue. A pronounced reactive astrogliosis was found 8-14 days after trauma, both as networks around the focal hemorrhages and more diffusely in several brain regions. Astrocytosis was prominent in the gray matter of the cerebral cortex, layers II-V, and in the granule cell layer and around the axons of the pyramidal neurons in the hippocampus. The nuclei of cranial nerves, such as the hypoglossal and facial nerves, also showed intense astrocytosis. The new model allows study of brain injuries from head rotation in the absence of translational influences.

Place, publisher, year, edition, pages
2001. Vol. 18, no 3, p. 247-257
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-251508DOI: 10.1089/08977150151070874OAI: oai:DiVA.org:kth-251508DiVA, id: diva2:1315743
Note

QCR 20190618

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-06-18Bibliographically approved

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