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Botulinum toxin A does not improve cast treatment for idiopathic toe-walking-a randomized controlled trial
Karolinska Institutet, Department of Women's and Children's Health. (Biomechanics)
2013 (English)In: Journal of Bone and Joint Surgery. American volume, ISSN 0021-9355, E-ISSN 1535-1386, Vol. 95, no 5, p. 400-407Article in journal (Refereed) Published
Abstract [en]

ACKGROUND:

There are many treatments for idiopathic toe-walking, including casts with or without injection of botulinum toxin A. Combined treatment with casts and botulinum toxin A has become more common even though there have been few studies of its efficacy and safety problems. Our aims were to conduct a randomized controlled trial to test the hypotheses that combined treatment with casts and botulinum toxin A is more effective than casts alone in reducing toe-walking by patients five to fifteen years of age, and that the treatment effect correlates with the extent of coexisting neuropsychiatric problems.

METHODS:

All patients who had been consecutively admitted to the pediatric orthopaedics department of our institution because of idiopathic toe-walking between November 2005 and April 2010 were considered for inclusion in the study. Forty-seven children constituted the study population. The children were randomized to undergo four weeks of treatment with below-the-knee casts either as the sole intervention or to undergo the cast treatment one to two weeks after receiving injections of botulinum toxin A into the calves. Before treatment and three and twelve months after cast removal, all children underwent three-dimensional (3-D) gait analysis. The severity of the idiopathic toe-walking was classified on the basis of the gait analysis, and the parents rated the time that their child spent on his/her toes during barefoot walking. Passive hip, knee, and ankle motion as well as ankle dorsiflexor strength were measured. Before treatment, all children were evaluated with a screening questionnaire for neuropsychiatric problems.

RESULTS:

No differences were found in any outcome parameter between the groups before treatment or at three or twelve months after cast removal. Several gait-analysis parameters, passive ankle motion, and ankle dorsiflexor strength were improved at both three and twelve months in both groups, even though many children still demonstrated some degree of toe-walking. The treatment outcomes were not correlated with coexisting neuropsychiatric problems.

CONCLUSION:

Adding botulinum toxin-A injections prior to cast treatment for idiopathic toe-walking does not improve the outcome of cast-only treatment.

TRIAL REGISTRATION: ClinicalTrials.gov NCT01590693.

Place, publisher, year, edition, pages
2013. Vol. 95, no 5, p. 400-407
National Category
Orthopaedics
Identifiers
URN: urn:nbn:se:kth:diva-251517OAI: oai:DiVA.org:kth-251517DiVA, id: diva2:1315827
Note

QCR 20190626

Available from: 2019-05-15 Created: 2019-05-15 Last updated: 2019-06-26Bibliographically approved

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