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Pressure and flow properties of cannulae for extracorporeal membrane oxygenation I: return (arterial) cannulae
Karolinska Univ Hosp, ECMO Ctr Karolinska, Dept Pediat Perioperat Med & Intens Care, Eugeniavagen 23, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;EuroElso, Working Grp Innovat & Technol, Newcastle Upon Tyne, Tyne & Wear, England..ORCID iD: 0000-0003-4124-4581
KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, School of Engineering Sciences (SCI), Centres, BioMEx.ORCID iD: 0000-0001-9976-8316
Karolinska Univ Hosp, ECMO Ctr Karolinska, Dept Pediat Perioperat Med & Intens Care, Eugeniavagen 23, S-17176 Stockholm, Sweden..
Maastricht Univ, Dept Cardiothorac Surg, Heart & Vasc Ctr, Cardiovasc Res Inst Maastricht CARIM,Med Hosp, Maastricht, Netherlands.;Maastricht Univ, Dept Physiol, Maastricht, Netherlands..
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2019 (English)In: Perfusion, ISSN 0267-6591, E-ISSN 1477-111X, Vol. 34, p. 58-64Article in journal (Refereed) Published
Abstract [en]

Adequate extracorporeal membrane oxygenation support in the adult requires cannulae permitting blood flows up to 6-8 L/minute. In accordance with Poiseuille's law, flow is proportional to the fourth power of cannula inner diameter and inversely proportional to its length. Poiseuille's law can be applied to obtain the pressure drop of an incompressible, Newtonian fluid (such as water) flowing in a cylindrical tube. However, as blood is a pseudoplastic non-Newtonian fluid, the validity of Poiseuille's law is questionable for prediction of cannula properties in clinical practice. Pressure-flow charts with non-Newtonian fluids, such as blood, are typically not provided by the manufacturers. A standardized laboratory test of return (arterial) cannulae for extracorporeal membrane oxygenation was performed. The aim was to determine pressure-flow data with human whole blood in addition to manufacturers' water tests to facilitate an appropriate choice of cannula for the desired flow range. In total, 14 cannulae from three manufacturers were tested. Data concerning design, characteristics, and performance were graphically presented for each tested cannula. Measured blood flows were in most cases 3-21% lower than those provided by manufacturers. This was most pronounced in the narrow cannulae (15-17 Fr) where the reduction ranged from 27% to 40% at low flows and 5-15% in the upper flow range. These differences were less apparent with increasing cannula diameter. There was a marked disparity between manufacturers. Based on the measured results, testing of cannulae including whole blood flows in a standardized bench test would be recommended.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD , 2019. Vol. 34, p. 58-64
Keywords [en]
arterial, return, extracorporeal membrane oxygenation, cannula, pressure flow, blood, water, extracorporeal life support
National Category
Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:kth:diva-251340DOI: 10.1177/0267659119830521ISI: 000464422000008PubMedID: 30966910Scopus ID: 2-s2.0-85064316040OAI: oai:DiVA.org:kth-251340DiVA, id: diva2:1317085
Conference
8th Euro-ELSO Congress (EuroELSO), APR 10-13, 2019, Barcelona, SPAIN
Note

QC 20190521

Available from: 2019-05-21 Created: 2019-05-21 Last updated: 2019-05-21Bibliographically approved

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Prahl Wittberg, Lisa

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