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Pressure and flow properties of cannulae for extracorporeal membrane oxygenation II: drainage (venous) cannulae
Karolinska Univ Hosp, Dept Pediat Perioperat Med & Intens Care, ECMO Ctr Karolinska, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;EuroELSO, Working Grp Innovat & Technol, Newcastle Upon Tyne, Tyne & Wear, England..ORCID iD: 0000-0003-4124-4581
KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, School of Engineering Sciences (SCI), Centres, BioMEx.ORCID iD: 0000-0001-9976-8316
Karolinska Univ Hosp, Dept Pediat Perioperat Med & Intens Care, ECMO Ctr Karolinska, S-17176 Stockholm, Sweden..
Maastricht Univ, Hosp Med, Cardiovasc Res Inst Maastricht CARIM, Heart & Vasc Ctr,Dept Cardiothorac Surg, Maastricht, Netherlands.;Maastricht Univ, Dept Physiol, Maastricht, Netherlands..
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2019 (English)In: Perfusion, ISSN 0267-6591, E-ISSN 1477-111X, Vol. 34, p. 65-73Article in journal (Refereed) Published
Abstract [en]

The use of extracorporeal life support devices such as extracorporeal membrane oxygenation in adults requires cannulation of the patient's vessels with comparatively large diameter cannulae to allow circulation of large volumes of blood (>5 L/min). The cannula diameter and length are the major determinants for extracorporeal membrane oxygenation flow. Manufacturing companies present pressure-flow charts for the cannulae; however, these tests are performed with water. Aims of this study were 1. to investigate the specified pressure-flow charts obtained when using human blood as the circulating medium and 2. to support extracorporeal membrane oxygenation providers with pressure-flow data for correct choice of the cannula to reach an optimal flow with optimal hydrodynamic performance. Eighteen extracorporeal membrane oxygenation drainage cannulae, donated by the manufacturers (n = 6), were studied in a centrifugal pump driven mock loop. Pressure-flow properties and cannula features were described. The results showed that when blood with a hematocrit of 27% was used, the drainage pressure was consistently higher for a given flow (range 10%-350%) than when water was used (data from each respective manufacturer's product information). It is concluded that the information provided by manufacturers in line with regulatory guidelines does not correspond to clinical performance and therefore may not provide the best guidance for clinicians.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD , 2019. Vol. 34, p. 65-73
Keywords [en]
drainage, cannula, pressure, flow, extracorporeal membrane oxygenation, extracorporeal, life support, venous
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:kth:diva-251339DOI: 10.1177/0267659119830514ISI: 000464422000009PubMedID: 30966909Scopus ID: 2-s2.0-85064320258OAI: oai:DiVA.org:kth-251339DiVA, id: diva2:1317588
Conference
8th Euro-ELSO Congress (EuroELSO), APR 10-13, 2019, Barcelona, SPAIN
Note

QC 20190523

Available from: 2019-05-23 Created: 2019-05-23 Last updated: 2019-05-23Bibliographically approved

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Prahl Wittberg, Lisa

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