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Clinical proteomics and molecular pathology
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-7674-2014
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2017 (English)In: Molecular Pathology: The Molecular Basis of Human Disease, Elsevier Inc. , 2017, p. 183-203Chapter in book (Other academic)
Abstract [en]

Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient. The next revolution is the synthesis of proteomic information into functional pathways and circuits in cells and tissues. Such synthesis must take into account the dynamic state of protein post-translational modifications; protein-protein or protein-DNA/RNA interactions; cross-talk between signal pathways; and feedback regulation within cells, between cells, and between tissues. This full set of information may be required before we can fully dissect the specific dysregulated pathways driving tumorigenesis. This higher level of functional understanding will be the basis for true rational therapeutic design that specifically targets the molecular lesions underlying human disease. 

Place, publisher, year, edition, pages
Elsevier Inc. , 2017. p. 183-203
Keywords [en]
Analyte, Antibody, Biomarker, Microdissection, Proteomics, Tumorigenesis
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:kth:diva-246926DOI: 10.1016/B978-0-12-802761-5.00009-2Scopus ID: 2-s2.0-85054332892ISBN: 9780128027615 (print)OAI: oai:DiVA.org:kth-246926DiVA, id: diva2:1327181
Note

QC 20190619

Available from: 2019-06-19 Created: 2019-06-19 Last updated: 2019-06-19Bibliographically approved

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Fredolini, Claudia

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Science for Life Laboratory, SciLifeLab
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