Composite biomolecule/PEDOT materials for neural electrodes
2008 (English)In: Biointerphases, ISSN 1559-4106, Vol. 3, no 3, 83-93 p.Article in journal (Refereed) Published
Electrodes intended for neural communication must be designed to meet boththe electrochemical and biological requirements essential for long term functionality. Metallic electrode materials have been found inadequate to meet theserequirements and therefore conducting polymers for neural electrodes have emergedas a field of interest. One clear advantage with polymerelectrodes is the possibility to tailor the material to haveoptimal biomechanical and chemical properties for certain applications. To identifyand evaluate new materials for neural communication electrodes, three chargedbiomolecules, fibrinogen, hyaluronic acid (HA), and heparin are used ascounterions in the electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). The resultingmaterial is evaluated electrochemically and the amount of exposed biomoleculeon the surface is quantified. PEDOT:biomolecule surfaces are also studiedwith static contact angle measurements as well as scanning electronmicroscopy and compared to surfaces of PEDOT electrochemically deposited withsurfactant counterion polystyrene sulphonate (PSS). Electrochemical measurements show that PEDOT:heparinand PEDOT:HA, both have the electrochemical properties required for neuralelectrodes, and PEDOT:heparin also compares well to PEDOT:PSS. PEDOT:fibrinogen isfound less suitable as neural electrode material.
Place, publisher, year, edition, pages
NY: American Institute of Physics , 2008. Vol. 3, no 3, 83-93 p.
composite materials, electrochemistry, electrodes, molecular biophysics, polymerisation, polymers, scanning electron microscopy
Inorganic Chemistry Other Materials Engineering
IdentifiersURN: urn:nbn:se:kth:diva-9843DOI: 10.1116/1.2998407ISI: 000264979200017ScopusID: 2-s2.0-69049086148OAI: oai:DiVA.org:kth-9843DiVA: diva2:133558
QC 201006232009-01-122009-01-122011-07-06Bibliographically approved