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Different Molecular Interaction between Collagen and alpha- or beta-Chitin in Mechanically Improved Electrospun Composite
Pohang Univ Sci & Technol POSTECH, Div Environm Sci & Engn, 77 Chengam Ro, Pohang 37673, South Korea..
Pohang Univ Sci & Technol POSTECH, Div Integrat Biosci & Biotechnol, 77 Chengam Ro, Pohang 37673, South Korea..ORCID iD: 0000-0002-4205-5371
Kangwon Natl Univ, Inst Mol Sci & Fus Technol, Dept Chem, Chunchon 24341, South Korea..
Kangwon Natl Univ, Inst Mol Sci & Fus Technol, Dept Chem, Chunchon 24341, South Korea..
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2019 (English)In: Marine Drugs, ISSN 1660-3397, E-ISSN 1660-3397, Vol. 17, no 6, article id 318Article in journal (Refereed) Published
Abstract [en]

Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which are the cause of the mechanical improvement in the composites were investigated by two-dimensional correlation spectroscopy (2DCOS). The electrospun collagen is composed of two kinds of polymorphs, alpha- and beta-chitin, showing different mechanical enhancement and molecular interactions due to different inherent configurations in the crystal structure, resulting in solvent and polymer susceptibility. The collagen/alpha-chitin has two distinctive phases in the composite, but beta-chitin composite has a relatively homogeneous phase. The beta-chitin composite showed better tensile strength with similar to 41% and similar to 14% higher strength compared to collagen and alpha-chitin composites, respectively, due to a favorable secondary interaction, i.e., inter- rather than intra-molecular hydrogen bonds. The revealed molecular interaction indicates that beta-chitin prefers to form inter-molecular hydrogen bonds with collagen by rearranging their uncrumpled crystalline regions, unlike alpha-chitin.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 17, no 6, article id 318
Keywords [en]
chitin, collagen, electrospinning, mechanical property, 2D correlation spectroscopy, polymorph
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-255581DOI: 10.3390/md17060318ISI: 000475305700007PubMedID: 31151236Scopus ID: 2-s2.0-85066935014OAI: oai:DiVA.org:kth-255581DiVA, id: diva2:1340781
Note

QC 20190806

Available from: 2019-08-06 Created: 2019-08-06 Last updated: 2019-08-06Bibliographically approved

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Koo, Jun Mo

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