Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Membrane Electroporation and Electropermeabilization: Mechanisms and Models
Univ Ljubljana, Fac Elect Engn, SI-1000 Ljubljana, Slovenia..
KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-7470-4367
Univ Lorraine, CNRS, LPCT, F-54000 Nancy, France..
Univ Ljubljana, Fac Elect Engn, SI-1000 Ljubljana, Slovenia..
2019 (English)In: Annual Review of Biophysics, vol 48, Annual Reviews Inc. , 2019, no RAELACHVILI JN, 1984, JOURNAL OF COLLOID AND INTERFACE SCIENCE, V98, P500 zer Esin B., 2018, JOURNAL OF MEMBRANE BIOLOGY, V251, P197 aviso Gale L., 2010, CELLULAR AND MOLECULAR NEUROBIOLOGY15th International Symposium on Chromaffin Cell Biology, NOV 12-16, 2009, Merida, MEXICO, V30, P1259, p. 63-91Chapter in book (Refereed)
Abstract [en]

Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing transmembrane transport of otherwise impermeant molecules. In recent years, large steps were made in the understanding of underlying events. Formation of aqueous pores in the lipid bilayer is now a widely recognized mechanism, but evidence is growing that changes to individual membrane lipids and proteins also contribute, substantiating the need for terminological distinction between electroporation and electropermeabilization. We first revisit experimental evidence for electrically induced membrane permeability, its correlation with transmembrane voltage, and continuum models of electropermeabilization that disregard the molecular-level structure and events. We then present insights from molecular-level modeling, particularly atomistic simulations that enhance understanding of pore formation, and evidence of chemical modifications of membrane lipids and functional modulation of membrane proteins affecting membrane permeability. Finally, we discuss the remaining challenges to our full understanding of electroporation and electropermeabilization.

Place, publisher, year, edition, pages
Annual Reviews Inc. , 2019. no RAELACHVILI JN, 1984, JOURNAL OF COLLOID AND INTERFACE SCIENCE, V98, P500 zer Esin B., 2018, JOURNAL OF MEMBRANE BIOLOGY, V251, P197 aviso Gale L., 2010, CELLULAR AND MOLECULAR NEUROBIOLOGY15th International Symposium on Chromaffin Cell Biology, NOV 12-16, 2009, Merida, MEXICO, V30, P1259, p. 63-91
Series
Annual Review of Biophysics, ISSN 1936-122X ; 48
Keywords [en]
pulsed electric field treatment, cell membrane, aqueous pores in lipid bilayers, transmembrane molecular transport, theoretical model, molecular dynamics
National Category
Biophysics
Identifiers
URN: urn:nbn:se:kth:diva-255588DOI: 10.1146/annurev-biophys-052118-115451ISI: 000475728600004PubMedID: 30786231Scopus ID: 2-s2.0-85065832199ISBN: 978-0-8243-1848-2 (print)OAI: oai:DiVA.org:kth-255588DiVA, id: diva2:1341390
Note

QC 20190808

Available from: 2019-08-08 Created: 2019-08-08 Last updated: 2019-08-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Rems, Lea

Search in DiVA

By author/editor
Rems, Lea
By organisation
BiophysicsScience for Life Laboratory, SciLifeLab
Biophysics

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
isbn
urn-nbn

Altmetric score

doi
pubmed
isbn
urn-nbn
Total: 26 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf