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Crystal Growth Kinetics of Piracetam Polymorphs in Ethanol and Isopropanol
Univ Limerick, Dept Chem & Environm Sci, Synth & Solid State Pharmaceut Ctr SSPC, Bernal Inst, Limerick V94 T9PX, Ireland..ORCID iD: 0000-0002-9988-7494
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemical Engineering, Transport Phenomena. Univ Limerick, Dept Chem & Environm Sci, Synth & Solid State Pharmaceut Ctr SSPC, Bernal Inst, Limerick V94 T9PX, Ireland.ORCID iD: 0000-0003-1790-2310
2019 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 19, no 8, p. 4273-4286Article in journal (Refereed) Published
Abstract [en]

The crystal growth kinetics of two different polymorphs of Piracetam have been investigated in ethanol and isopropanol. Isothermal seeded desupersaturation experiments were carried out at supersaturation ratios below 1.2 within the range of temperature 283-308 K. Liquid concentration was determined by in situ ATR-FTIR spectroscopy by a calibration-free method using principal component analysis. The power law equation and the BCF and B+S models were fitted to the experimental desupersaturation data by nonlinear optimization. The growth rates ranged 10(-7)-10(-8) m/s, the growth rate order is clearly higher than unity, and the activation energies are in the range 39-66 kJ/mol for all the systems studied suggesting surface integration control. The growth of the metastable polymorph is faster than that of the stable form in both solvents. The crystal growth proceeds faster in ethanol than in isopropanol for both polymorphs. The solid-liquid interfacial energy is lower for the metastable form and is for both forms lower in ethanol than in isopropanol. The surface diffusion mass transfer rate is higher for the metastable form compared to the stable form and higher in ethanol than in isopropanol.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019. Vol. 19, no 8, p. 4273-4286
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Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-257459DOI: 10.1021/acs.cgd.8b01733ISI: 000480499600011Scopus ID: 2-s2.0-85070920349OAI: oai:DiVA.org:kth-257459DiVA, id: diva2:1347110
Note

QC 20190830

Available from: 2019-08-30 Created: 2019-08-30 Last updated: 2019-08-30Bibliographically approved

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Rasmuson, Åke C.

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