Silicon Nanoribbons for Electrical Detection of Biomolecules
2008 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 8, no 3, 945-949 p.Article in journal (Refereed) Published
Direct electrical detection of biomolecules at high sensitivity hat recently been demonstrated using semiconductor nanowires. Here we demonstrate that semiconductor nanoribbons, in this case, a thin sheet of silicon on an oxidized silicon substrate, can approach the same sensitivity extending below the picomolar concentration regime in the biotin/streptavidin case. This corresponds to less than similar to 20 analyte molecules bound to receptors on the nanoribbon surface. The micrometer-size lateral dimensions of the nanoribbon enable optical lithography to be used, resulting in a simple and high-yield fabrication process. Electrical characterization of the nanoribbons is complemented by computer simulations showing enhanced sensitivity for thin ribbons. Finally, we demonstrate that the device can be operated both in inversion as well as in accumulation mode and the measured differences in detection sensitivity are explained in terms of the distance between the channel and the receptor coated surface with respect to the Debye screening length. The nanoribbon approach opens up for large scale CMOS fabrication of highly sensitive biomolecule sensor chips for potential use in medicine and biotechnology.
Place, publisher, year, edition, pages
2008. Vol. 8, no 3, 945-949 p.
Biomolecules; Electric conductivity; Electric wire; Photolithography; Semiconducting silicon; Semiconductor materials; Thickness measurement; Accumulation modes; Analyte molecules; CMOS fabrications; Coated surfaces; Debye screening lengths; Detection sensitivities; Electrical characterizations; Electrical detections; Enhanced sensitivities; Fabrication process; High sensitivities; Highly sensitives; Lateral dimensions; Nanoribbon; Nanoribbons; Optical lithographies; Oxidized silicon substrates; Semiconductor nanoribbons; Semiconductor nanowires; Sensor chips; Thin ribbons; Thin sheets
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-8221DOI: 10.1021/nl080094rISI: 000253947400033ScopusID: 2-s2.0-43149112560OAI: oai:DiVA.org:kth-8221DiVA: diva2:13482
QC 201007162008-04-092008-04-092010-07-19Bibliographically approved