Enantioselective Organocatalytic Hydrophosphination of α,β-Unsaturated Aldehydes
2007 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 46, no 24, 4507-4510 p.Article in journal (Refereed) Published
Keeping it simple: Optically active phosphine derivatives can be obtained in high yields and in up to 99% ee by using simple chiral amines to catalyze the hydrophosphination of α,β-unsaturated aldehydes (see scheme, green sphere = chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of β-phosphine oxide acids.
Place, publisher, year, edition, pages
2007. Vol. 46, no 24, 4507-4510 p.
Aldehydes, Asymmetric synthesis, Conjugate addition, Organocatalysis, Phosphanes
Other Basic Medicine
IdentifiersURN: urn:nbn:se:kth:diva-8241DOI: 10.1002/anie.200700916ISI: 000247500600018ScopusID: 2-s2.0-34250780536OAI: oai:DiVA.org:kth-8241DiVA: diva2:13510
QC 201007162008-04-222008-04-222010-11-11Bibliographically approved