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The Potential Use of Metabolic Cofactors in Treatment of NAFLD
KTH, Centres, Science for Life Laboratory, SciLifeLab.
Koc Univ, Sch Med, TR-34450 Istanbul, Turkey..
Koc Univ, Sch Med, Dept Gastroenterol & Hepatol, TR-34450 Istanbul, Turkey..
KTH, Centres, Science for Life Laboratory, SciLifeLab.
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2019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 7, article id 1578Article, review/survey (Refereed) Published
Abstract [en]

Non-alcoholic fatty liver disease (NAFLD) is caused by the imbalance between lipid deposition and lipid removal from the liver, and its global prevalence continues to increase dramatically. NAFLD encompasses a spectrum of pathological conditions including simple steatosis and non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver cancer. Even though there is a multi-disciplinary effort for development of a treatment strategy for NAFLD, there is not an approved effective medication available. Single or combined metabolic cofactors can be supplemented to boost the metabolic processes altered in NAFLD. Here, we review the dosage and usage of metabolic cofactors including l-carnitine, Nicotinamide riboside (NR), l-serine, and N-acetyl-l-cysteine (NAC) in human clinical studies to improve the altered biological functions associated with different human diseases. We also discuss the potential use of these substances in treatment of NAFLD and other metabolic diseases including neurodegenerative and cardiovascular diseases of which pathogenesis is linked to mitochondrial dysfunction.

Place, publisher, year, edition, pages
MDPI , 2019. Vol. 11, no 7, article id 1578
Keywords [en]
NAFLD, metabolic cofactors, l-carnitine, nicotinamide riboside, l-serine, N-acetyl-l-cysteine, SIMONE C, 1994, AIDS, V8, P655 rdinoglu Adil, 2015, SCIENTIFIC REPORTS, V5, laguarnera Mariano, 2010, AMERICAN JOURNAL OF GASTROENTEROLOGY, V105, P1338 rk Michael, 2013, TRENDS IN PHARMACOLOGICAL SCIENCES, V34, P167 odes Kate, 2017, SPORTS MEDICINE, V47, P1619 son J. K., 2014, FRONTLINE GASTROENTEROLOGY, V5, P277 oshbaten Manouchehr, 2010, HEPATITIS MONTHLY, V10, P12 llatori Nazzareno, 2009, BIOLOGICAL CHEMISTRY, V390, P191 stee Quentin M., 2013, NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, V10, P330 rofalo Kevin, 2011, JOURNAL OF CLINICAL INVESTIGATION, V121, P4735 idman Vera, 2019, NEUROLOGY, V92, PE359 u Zhengtao, 2017, HEPATOLOGY, V66, P1357 muk GE, 2003, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, V18, P1220 rdinoglu Adil, 2018, CELL SYSTEMS, V6, P7 rdinoglu Adil, 2018, CELL METABOLISM, V27, P559 iels Martin, 2015, FRONTIERS IN PHYSIOLOGY, V6, Koning TJ, 2004, LANCET, V364, P2221 Koning TJ, 2006, JOURNAL OF INHERITED METABOLIC DISEASE42nd Annual Meeting of the Society-for-the-Study-of-Inborn-Errors-of-Metabolism, SEP 06-09, 2005, Paris, FRANCE, V29, P347
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:kth:diva-257580DOI: 10.3390/nu11071578ISI: 000478885400021PubMedID: 31336926Scopus ID: 2-s2.0-85070473044OAI: oai:DiVA.org:kth-257580DiVA, id: diva2:1353059
Note

QC 20190920

Available from: 2019-09-20 Created: 2019-09-20 Last updated: 2020-01-10Bibliographically approved

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Mardinoglu, AdilUhlén, Mathias

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