Direct Asymmetric Dynamic Kinetic Resolution by Combined Lipase Catalysis and Nitroaldol (Henry) Reaction
2008 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 350, no 3, 448-452 p.Article in journal (Refereed) Published
The asymmetric synthesis of β-nitroalkanol derivatives was simply achieved by a combined nitroaldol (Henry) reaction with lipase-catalyzed transesterification in high yield and enantiomeric purity (up to 92% and 99% ee) through a direct one-pot procedure.
Place, publisher, year, edition, pages
2008. Vol. 350, no 3, 448-452 p.
Dynamic kinetic resolution; Enzyme catalysis; Nitroaldol (Henry) reaction; Secondary alcohols
IdentifiersURN: urn:nbn:se:kth:diva-8264DOI: 10.1002/adsc.200700432ISI: 000253600600018ScopusID: 2-s2.0-49049106632OAI: oai:DiVA.org:kth-8264DiVA: diva2:13541
QC 201008182008-04-252008-04-252010-08-18Bibliographically approved