Dynamic Combinatorial Resolution: Direct Asymmetric Lipase-Mediated Screening of a Dynamic Nitroaldol Library
2007 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 46, no 6, 948-950 p.Article in journal (Refereed) Published
(Chemical Equation Presented) A disturbance in the library: The nitroaldol (Henry) reaction was developed as an efficient C-C bond-forming route to dynamic combinatorial libraries (DCLs). These DCLs generated under thermodynamic control were coupled in a one-pot process with kinetically controlled lipase-mediated transesterification (see scheme). The asymmetric resolution of the DCLs by the enzyme led to enantiomerically pure β-nitroacetates in high yield.
Place, publisher, year, edition, pages
2007. Vol. 46, no 6, 948-950 p.
Aldol reaction; Combinatorial chemistry; Dynamic chemistry; Enzyme catalysis; Reversible reactions
IdentifiersURN: urn:nbn:se:kth:diva-8267DOI: 10.1002/anie.200603740ISI: 000244146500026ScopusID: 2-s2.0-33846687723OAI: oai:DiVA.org:kth-8267DiVA: diva2:13544
QC 201005062008-04-252008-04-252010-08-18Bibliographically approved