Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Investigation of the solid-state polymorphic transformations of piracetam
Show others and affiliations
2012 (English)In: Crystal Growth and Design, Vol. 12, no 12, p. 6223-6233Article in journal (Refereed) Published
Abstract [en]

The solid-state polymorphic transformations of 2-oxo-1-pyrrolidine acetamide (piracetam) were investigated using a combination of off-line and online techniques: differential scanning calorimetry (DSC), high temperature X-ray diffraction (HT-XRD), thermal analysis, and hot-stage optical microscopy. Form II and Form III were each observed to transform directly to Form I upon heating, with Form II transforming at a slightly lower temperature. The transformation of both polymorphs to Form I was observed to cause physical cracking of the crystals as well as changing the optical properties. Form I consistently transformed to Form II when cooled. The molecular rearrangements required for the transformation from Form I to Form II were found to be more energetically favorable than those required for the transformation to Form III. The transformation from the metastable Form II to the stable Form III was not observed in the solid-state, while the Form II-Form III transition temperature was found to be higher than the transition temperature of both polymorphs to Form I.

Place, publisher, year, edition, pages
2012. Vol. 12, no 12, p. 6223-6233
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-260461DOI: 10.1021/cg301418cISI: 000311858600051Scopus ID: 2-s2.0-84870790838OAI: oai:DiVA.org:kth-260461DiVA, id: diva2:1355627
Note

QC 20190930

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-09-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records BETA

Rasmuson, Åke C.

Search in DiVA

By author/editor
Rasmuson, Åke C.
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf