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Controlling the Product Crystal Size Distribution by Strategic Application of Ultrasonication
University of Limerick.ORCID iD: 0000-0003-1790-2310
2018 (English)In: Crystal Growth & Design, ISSN 1528-7483, Vol. 18, no 3, p. 1697-1709Article in journal (Refereed) Published
Abstract [en]

In this work, different strategies of ultrasonication (continuous, single pulse, and multiple pulse) are compared for control of the product crystal size distribution of three model API compounds: piracetam, paracetamol, and ibuprofen. Experiments have been performed on 0.5 and 3 L scales continuously recorded by FTIR and FBRM. Irrespective of the sonication operating mode, sonication in general produced smaller sized crystals with a more narrow size distribution in comparison to those for a normal cooling crystallization process. A multiple-pulse sonication mode, in particular, was capable of delivering more narrow size distributions. Sonication power per unit mass of solution does not appear to be a relevant scaling-up parameter.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2018. Vol. 18, no 3, p. 1697-1709
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-260101DOI: 10.1021/acs.cgd.7b01619ISI: 000427203700050Scopus ID: 2-s2.0-85043302292OAI: oai:DiVA.org:kth-260101DiVA, id: diva2:1355917
Note

Cited By :3; Export Date: 25 September 2019

QC 20191029

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-10-29Bibliographically approved

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Rasmuson, Åke Christoffer
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