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Advanced Size Distribution Control in Batch Cooling Crystallization Using Ultrasound
Univ Limerick, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Dept Chem & Environm Sci, Limerick, Ireland.
Univ Limerick, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Dept Chem & Environm Sci, Limerick, Ireland.ORCID iD: 0000-0003-4244-4542
Univ Limerick, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Dept Chem & Environm Sci, Limerick, Ireland.ORCID iD: 0000-0003-1790-2310
2019 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 23, no 5, p. 935-944Article in journal (Refereed) Published
Abstract [en]

The combination of a small sonicated crystallizer operated as a seed generator with a large normal batch cooling crystallizer for growth of the seeds has been investigated. Altering the sonication power and time allows the number of seeds generated to be controlled. By control of the conditions in the large crystallizer, a narrow size distribution of crystals of a controlled size can be obtained. Piracetam was used as the model compound, and various process analytical technologies were used in examining the process. Commercial software was used for determination of the growth kinetics, and it is shown that the model predictions very well match the product size of the experiments.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019. Vol. 23, no 5, p. 935-944
Keywords [en]
sonocrystallization, crystallization, growth kinetics, ultrasound, size control, process modeling, Dynochem
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-260097DOI: 10.1021/acs.oprd.9b00033ISI: 000468697300026Scopus ID: 2-s2.0-85065845218OAI: oai:DiVA.org:kth-260097DiVA, id: diva2:1355929
Note

QC 20191106

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-11-06Bibliographically approved

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Kumar, Kannuchamy VasanthRasmuson, Åke Christoffer
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