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Process Parameters in the Purification of Curcumin by Cooling Crystallization
University of Limerick.ORCID iD: 0000-0003-1790-2310
2016 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 20, no 9, p. 1593-1602Article in journal (Refereed) Published
Abstract [en]

Purification of crude curcumin by up to four successive cooling crystallizations has been investigated for a wide variety of process conditions. For each crystallization step the influence of various processing conditions on crystal purity, polymorphic outcome, and crystal size and shape is reported. By an extensive number of experiments according to a statistical experimental design, the influence on cooling rate, seeding, seed polymorph, and agitation conditions has been identified. Slow cooling and seeding, particularly with the metastable Form II seed, significantly improves the purification. A correlation between product crystal size and purity is found. By tuning the crystallization parameters the number of recrystallization steps required to reach a certain purity can be reduced, which significantly increased the overall curcumin yield from 28% to 50%.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 20, no 9, p. 1593-1602
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:kth:diva-260109DOI: 10.1021/acs.oprd.6b00153ISI: 000383640100005Scopus ID: 2-s2.0-84987893055OAI: oai:DiVA.org:kth-260109DiVA, id: diva2:1355936
Note

Cited By :7; Export Date: 25 September 2019

QC 20191030

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-10-30Bibliographically approved

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Rasmuson, Åke Christoffer
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