Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Extraction and Purification of Curcuminoids from Crude Curcumin by a Combination of Crystallization and Chromatography
Show others and affiliations
2017 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 21, no 6, p. 821-826Article in journal (Refereed) Published
Abstract [en]

In this work a method is developed for the extraction and purification of the three curcuminoids, curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC), from commercially available crude curcumin. In a previous publication the extraction of pure curcumin by repeated crystallization has been described. The focus of this paper is on the following chromatographic treatment of the mother liquor from the crystallization to obtain pure DMC and BDMC and to increase the yield of pure CUR. In the chromatographic process, a mixture of chloroform and methanol is used as the mobile phase, and silica gel is used as the stationary phase. Each fraction isolated in the chromatographic process was characterized by high-performance liquid chromatography (HPLC) and mass spectrometry (LC-MS) techniques, and the pure CUR, DMC, and BDMC solid phases were fully characterized by powder Xray diffraction (PXRD), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). Stability studies were performed on the purified curcuminoids where the degradation products were observed and analyzed by HPLC/LC-MS. Overall, the combined purification method recovered from the crude: 88.5%, 79.7%, and 68.8% of CUR, DMC, and BDMC, respectively, in highly pure form CUR (100%), DMC (98.6%), and BDMC (98.3%). © 2017 American Chemical Society.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 21, no 6, p. 821-826
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-260105DOI: 10.1021/acs.oprd.6b00347ISI: 000403854800003Scopus ID: 2-s2.0-85020943212OAI: oai:DiVA.org:kth-260105DiVA, id: diva2:1355955
Note

QC 20191025

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-10-25Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopushttps://www2.scopus.com/inward/record.uri?eid=2-s2.0-85020943212&doi=10.1021%2facs.oprd.6b00347&partnerID=40&md5=79fb2a434d40041aea181a6c60fd479d

Search in DiVA

By author/editor
Rasmuson, Åke Christoffer
In the same journal
Organic Process Research & Development
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 13 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf