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Nucleation in the p-toluenesulfonamide/triphenylphosphine oxide co-crystal system
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemical Engineering. Univ Limerick, Mat & Surface Sci Inst, Dept Chem & Environm Sci.ORCID iD: 0000-0003-1790-2310
2013 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 13, no 8, p. 3754-3762Article in journal (Refereed) Published
Abstract [en]

Nucleation has been studied in pure co-crystal and mixed co-crystal phase regions of the ternary phase diagram (TPD) in acetonitrile at 20 C using cooling crystallization experiments. Direct nucleation of each of the co-crystal phases in this system was independently observed in regions of the TPD where each is stable. In mixed regions, regions where either a co-crystal and a coformer, or both co-crystals, are stable, the phase that initially nucleated was a function of the mass composition in that region. The relative amount of each phase nucleating could be controlled by adjusting the relative mass fraction of each component. The kinetic return to equilibrium was also observed as the systems were held over time, with the selected mass fractions always returning to the equilibrium dictated by the TPD after 24 h

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2013. Vol. 13, no 8, p. 3754-3762
Keywords [en]
PHARMACEUTICAL COCRYSTALS; PHASE-DIAGRAMS; NICOTINAMIDE; STABILITY
National Category
Chemical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-260116DOI: 10.1021/cg400780eISI: 000323020000061Scopus ID: 2-s2.0-84881406002OAI: oai:DiVA.org:kth-260116DiVA, id: diva2:1355983
Note

Cited By :7; Export Date: 25 September 2019; Article

QC 20191011

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-10-11Bibliographically approved

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