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Isothermal suspension conversion as a route to cocrystal production: One-pot scalable synthesis
University of Limerick.ORCID iD: 0000-0003-1790-2310
2014 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 18, no 8, p. 941-946Article in journal (Refereed) Published
Abstract [en]

Isothermal suspension conversion is presented as a suitable method for the manufacture of pure cocrystal products once the ternary phase diagram (TPD) for the cocrystal system in the desired solvent is available. One:one and 3:2 cocrystals of p-toluenesulphonamide/triphenylphosphine oxide were produced in acetonitrile and dichloromethane using this method. Eight individual batches of product were prepared with complete conversion to pure product achieved in seven batches. Product recovery (77-99%), reaction conversion (17-89%), and volumetric productivity (0.03-0.63 g/cm(3)) were calculated for each product batch. These parameters are essentially determined by the batch operating mass fraction composition selected from the TPD, allowing for tailoring of processing conditions to suit process requirements and capabilities by careful selection of the optimum operating mass fraction composition.

Place, publisher, year, edition, pages
2014. Vol. 18, no 8, p. 941-946
National Category
Chemical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-260581DOI: 10.1021/op500145aISI: 000340517100004Scopus ID: 2-s2.0-84906218352OAI: oai:DiVA.org:kth-260581DiVA, id: diva2:1356004
Note

Cited By :9; Export Date: 30 September 2019; Article

QC 20191011

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-10-11Bibliographically approved

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Rasmuson, Åke Christoffer
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