Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction
RAS, Kharkevich Inst Informat Transmiss Problems, Moscow, Russia.;European Mol Biol Lab, Heidelberg, Germany..
Pirogov Russian Natl Res Med Univ, Microbiol & Virol Dept, Moscow, Russia..
RAS, Kharkevich Inst Informat Transmiss Problems, Moscow, Russia.;IST Austria, Klosterneuburg, Austria..
RAS, Kharkevich Inst Informat Transmiss Problems, Moscow, Russia.;Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow, Russia.;RAS, Vavilov Inst Gen Genet, Moscow, Russia..
Show others and affiliations
2019 (English)In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 20, no 1, article id 710Article in journal (Refereed) Published
Abstract [en]

Background: Chlamydia are ancient intracellular pathogens with reduced, though strikingly conserved genome. Despite their parasitic lifestyle and isolated intracellular environment, these bacteria managed to avoid accumulation of deleterious mutations leading to subsequent genome degradation characteristic for many parasitic bacteria. Results: We report pan-genomic analysis of sixteen species from genus Chlamydia including identification and functional annotation of orthologous genes, and characterization of gene gains, losses, and rearrangements. We demonstrate the overall genome stability of these bacteria as indicated by a large fraction of common genes with conserved genomic locations. On the other hand, extreme evolvability is confined to several paralogous gene families such as polymorphic membrane proteins and phospholipase D, and likely is caused by the pressure from the host immune system. Conclusions: This combination of a large, conserved core genome and a small, evolvable periphery likely reflect the balance between the selective pressure towards genome reduction and the need to adapt to escape from the host immunity.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 20, no 1, article id 710
Keywords [en]
Chlamydia, Intracellular pathogens, Pan-genome, Genome evolution, Comparative genomics, PmpG
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:kth:diva-261314DOI: 10.1186/s12864-019-6059-5ISI: 000485256100001PubMedID: 31510914Scopus ID: 2-s2.0-85072126329OAI: oai:DiVA.org:kth-261314DiVA, id: diva2:1358322
Note

QC 20191007

Available from: 2019-10-07 Created: 2019-10-07 Last updated: 2019-10-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Akkuratov, Evgeny E.

Search in DiVA

By author/editor
Akkuratov, Evgeny E.
By organisation
BiophysicsScience for Life Laboratory, SciLifeLab
In the same journal
BMC Genomics
Bioinformatics and Systems Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 4 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf