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Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors
Isfahan Univ Med Sci, Sch Med, Dept Internal Med, Rheumatol Sect, Esfahan, Iran..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.ORCID iD: 0000-0002-1929-135X
Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran..ORCID iD: 0000-0002-7309-1105
Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran..
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2019 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 126, article id UNSP 103910Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of this study was to determine capillaroscopic changes in patients with systemic lupus erythematosus (SLE) and their predictors. Methods: Fifty-nine SLE patients and 31 controls were enrolled in a cross-sectional study. Nailfold capillaroscopy examinations were performed, and qualitative semi-quantitative and quantitative parameters were evaluated in all fingers. Demographic features and lupus characteristics, such as renal involvement, medications, laboratory data, disease activity (SLEDAI) and damage, were recorded. The predictors of capillaroscopic abnormalities were obtained by backward stepwise regression analysis. Results: Capillary numbers of right hands were significantly lower in patients than in controls [8.74 (1.66) vs. 9.63 (1.80), P = 0.0001]. Capillaries were wider in patients than in controls in right [56.32 pm (16.76) vs. 50.43 mu m (10.16), P = 0.002] and left hands [54.40 (15.02) vs. 49.71 (9.77), P = 0.005]. Capillaries were shorter in SLE patients than in controls. Multivariate analysis revealed that the main associative factors of microvascular abnormalities were gender, drinking tea and hydroxychloroquine use for giant capillaries, SLEDAI and low C3 for avascularity and age, lupus nephritis and corticosteroid use for ramification. Conclusion: Most nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2019. Vol. 126, article id UNSP 103910
Keywords [en]
Nailfold video capillaroscopy, Systemic lupus erythematosus, Microcirculation
National Category
Clinical Medicine
Research subject
Technology and Health
Identifiers
URN: urn:nbn:se:kth:diva-260985DOI: 10.1016/j.mvr.2019.103910ISI: 000485206200009PubMedID: 31408627Scopus ID: 2-s2.0-85070793764OAI: oai:DiVA.org:kth-260985DiVA, id: diva2:1359264
Note

QC 20191008

Available from: 2019-10-08 Created: 2019-10-08 Last updated: 2019-11-26Bibliographically approved

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Erlandsson, Björn-ErikKarbalaie, Abdolamir

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