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Influence of high hydrostatic pressure on solid supported DPPC bilayers with hyaluronan in the presence of Ca2+ ions
Helmholtz Zentrum Geesthacht, Ctr Mat & Costal Res, Inst Mat Res, Max Planck Str 1, D-21502 Geesthacht, Germany..
Helmholtz Zentrum Geesthacht, Ctr Mat & Costal Res, Inst Mat Res, Max Planck Str 1, D-21502 Geesthacht, Germany..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Surface and Corrosion Science.
TU Dortmund, DELTA, Fak Phys, D-44221 Dortmund, Germany..
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2019 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 15, no 36, p. 7295-7304Article in journal (Refereed) Published
Abstract [en]

The molecular mechanisms responsible for outstanding lubrication of natural systems, like articular joints, have been the focus of scientific research for several decades. One essential aspect is the lubrication under pressure, where it is important to understand how the lubricating entities adapt under dynamic working conditions in order to fulfill their function. We made a structural investigation of a model system consisting of two of the molecules present at the cartilage interface, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and hyaluronan, at high hydrostatic pressure. Phospholipid layers are found at the cartilage surfaces and are able to considerably reduce friction. Their behavior under load and varied solution conditions is important as pressures of 180 bar are encountered during daily life activities. We focus on how divalent ions, like Ca2+, affect the interaction between DPPC and hyaluronan, as other investigations have indicated that calcium ions influence their interaction. It could be shown that already low amounts of Ca2+ strongly influence the interaction of hyaluronan with DPPC. Our results suggest that the calcium ions increase the amount of adsorbed hyaluronan indicating an increased electrostatic interaction. Most importantly, we observe a modification of the DPPC phase diagram as hyaluronan absorbs to the bilayer which results in an L-alpha-like structure at low temperatures and a decoupling of the leaflets forming an asymmetric bilayer structure.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2019. Vol. 15, no 36, p. 7295-7304
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Physical Chemistry
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URN: urn:nbn:se:kth:diva-261946DOI: 10.1039/c9sm01066aISI: 000487085700017PubMedID: 31483431Scopus ID: 2-s2.0-85072354344OAI: oai:DiVA.org:kth-261946DiVA, id: diva2:1361087
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QC 20191015

Available from: 2019-10-15 Created: 2019-10-15 Last updated: 2019-10-15Bibliographically approved

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Raj, AkankshaDédinaité, AndraClaesson, Per M.

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