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High-definition spatial transcriptomics for in situ tissue profiling
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Gene Technology. Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA..ORCID iD: 0000-0003-0985-9885
Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA..
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2019 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 16, no 10, p. 987-+Article in journal (Refereed) Published
Abstract [en]

Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcriptcoupled spatial barcodes at 2-mu m resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 16, no 10, p. 987-+
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Biological Sciences
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URN: urn:nbn:se:kth:diva-262787DOI: 10.1038/s41592-019-0548-yISI: 000488225900027PubMedID: 31501547Scopus ID: 2-s2.0-85072716890OAI: oai:DiVA.org:kth-262787DiVA, id: diva2:1362937
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QC 20191022

Available from: 2019-10-22 Created: 2019-10-22 Last updated: 2019-10-22Bibliographically approved

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Vickovic, SanjaBergenstrahle, JosephFernandez Navarro, JoseLundeberg, JoakimStåhl, Patrik

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Vickovic, SanjaSalmen, FredrikStenbeck, LinneaSchapiro, DenisBergenstrahle, JosephFernandez Navarro, JoseLundeberg, JoakimStåhl, Patrik
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Science for Life Laboratory, SciLifeLabGene Technology
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