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Dissecting the spatiotemporal subcellular distribution of the human proteome
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Cellular and Clinical Proteomics.ORCID iD: 0000-0001-7034-0850
2019 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 27, p. 764-764Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Compartmentalization of biological reactions is an important mechanism to allow multiple cellular reactions to occur in parallel. Resolving the spatial distribution of the human proteome at a subcellular level increases our understanding of human biology and disease. We have generated a high-resolution map of the subcellular distribution of the human proteome as part of the open access Human Protein Atlas database. We have shown that as much as half of all proteins localize to multiple compartments. Such proteins may have context specific functions and ‘moonlight’ in different parts of the cell, thus increasing the functionality of the proteome and the complexity of the cell from a systems perspective. I will present how this spatial data can complement quantitative omics data for improved functional read-out. Furthermore, I will present unpublished data on the extent of single cell variations of the human proteome, in correlation to cell cycle progression and other deterministic factors, as well as the overlap with observed variations at the RNA level. In summary, I will demonstrate the importance of spatial proteomics data for improved single cell biology.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 27, p. 764-764
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-262994DOI: 10.1038/s41431-019-0407-4ISI: 000489313106038Scopus ID: 2-s2.0-85069267274OAI: oai:DiVA.org:kth-262994DiVA, id: diva2:1366969
Conference
51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG), JUN 16-19, 2018, Milan, ITALY
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20191031

Available from: 2019-10-31 Created: 2019-10-31 Last updated: 2019-10-31Bibliographically approved

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Lundberg, Emma

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