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SYNTHETIC MICROFLUIDIC PAPER WITH SUPERIOR FLUORESCENT SIGNAL READOUT
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems. (Microfluidics)
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems. (Microfluidics)ORCID iD: 0000-0001-8531-5607
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems. (Microfluidics)ORCID iD: 0000-0001-8248-6670
2019 (English)In: Proceedings of The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2019, p. 1056-1057Conference paper, Published paper (Refereed)
Abstract [en]

This work is the first report on the use of synthetic microfluidic paper for lateral flow immunoassays. We grafted test lines of biotin on the synthetic paper using the thiol-yne “click” reaction. We captured fluorescently labeled streptavidin in a lateral flow fashion. Our two main findings are that, compared to other polymer lateral flow substrates with similar surface area, the synthetic microfluidic paper geometry results in 1) a stronger and more stable fluorescent signal per capture area, and 2) a sensitivity ~7 times higher.

Place, publisher, year, edition, pages
2019. p. 1056-1057
Keywords [en]
synthetic paper, fluorescent signal, biotin-steptavidin, OSTE, capillary, lateral flow test, off-stoichiometery thiol-ene, thiol-yne
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Paper, Pulp and Fiber Technology Polymer Technologies
Research subject
Biotechnology; Electrical Engineering; Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-263249ISBN: 978-1-7334190-0-0 (print)OAI: oai:DiVA.org:kth-263249DiVA, id: diva2:1367808
Conference
The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), 27-31 October 2019, Basel, SWITZERLAND
Projects
ND4ID
Note

QC 20191106

Available from: 2019-11-05 Created: 2019-11-05 Last updated: 2019-11-06Bibliographically approved

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Guo, WeijinHansson, Jonasvan der Wijngaart, Wouter

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