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Inhibition of cortical neural networks using infrared laser
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Neuronic Engineering. Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.;KTH Royal Inst Technol, Div Neuron Engn, Dept Biomed Engn & Hlth Syst, S-14157 Stockholm, Sweden..ORCID iD: 0000-0002-2990-6100
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Neuronic Engineering.
2019 (English)In: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648, Vol. 12, no 7Article in journal (Refereed) Published
Abstract [en]

The aim of the present study is to optimize parameters for inhibiting neuronal activity safely and investigating thermal inhibition of rat cortex neural networks in vitro by continuous infrared (IR) laser. Rat cortex neurons were cultured on multi-electrode arrays until neural networks were formed with spontaneous neural activity. Neurons were then irradiated to inhibit the activity of the networks using different powers of 1550 nm IR laser light. A finite element heating model, calibrated by the open glass pipette method, was used to calculate temperature increases at different laser irradiation intensities. A damage signal ratio (DSR) was evaluated to avoid excessive heating that may damage cells. The DSR predicted that cortex neurons should be safe at temperatures up to 49.6 degrees C for 30 seconds, but experiments suggested that cortex neurons should not be exposed to temperatures over 46 degrees C for 30 seconds. Neural response experiments showed that the inhibition of neural activity is temperature dependent. The normal neural activity could be inhibited safely with an inhibition degree up to 80% and induced epileptiform activity could be suppressed. These results show that continuous IR laser radiations provide a possible way to safely inhibit the neural network activity.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2019. Vol. 12, no 7
Keywords [en]
heating model, infrared laser, inhibition, neural activity, safe
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-256277DOI: 10.1002/jbio.201800403ISI: 000477683300017PubMedID: 30859700Scopus ID: 2-s2.0-85063693891OAI: oai:DiVA.org:kth-256277DiVA, id: diva2:1367970
Note

QC 20191105

Available from: 2019-11-05 Created: 2019-11-05 Last updated: 2019-11-05Bibliographically approved

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Xia, QinglingNyberg, Tobias

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