Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate
Show others and affiliations
2020 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 229, article id 115496Article in journal (Refereed) Published
Abstract [en]

Chondroitin sulfates (CS) account for more than 80% of glycosaminoglycans of articular cartilage, which imparts its physiological functions. We quantified the absolute concentration of the CS components of the full thickness cartilages from the knees of patients with terminal-phase osteoarthritis. Osteochondrol biopsies were removed from the medial femoral condyle and lateral femoral condyle of sixty female patients receiving total knee arthroplasty, aged from 58 to 83 years old. We found that total CS concentrations and chondroitin-4-sulfate disaccharide were significantly lowered in osteoarthritic samples. Microstructure analysis indicated that while chondroitin-0-sulfate was equally distributed across different zones of the osteoarthritic cartilages, chondroitin-4-sulfate is significantly less in the deep zones. Down-regulation of sulfotransferases, the enzymes responsible for CS sulfation in the lesion site of cartilage were observed. Our study suggested chondroitin-4-sulfate down-regulation may be a diagnostic marker for degraded osteoarthritis cartilage, with potential implications in cartilage regeneration.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 229, article id 115496
Keywords [en]
Chondroitin sulfate, Sulfotransferase, Sulfatase, Osteoarthritis, Adult cartilage
National Category
Pharmaceutical Sciences Analytical Chemistry Geriatrics
Identifiers
URN: urn:nbn:se:kth:diva-263307DOI: 10.1016/j.carbpol.2019.115496ISI: 000501796600125PubMedID: 31826425Scopus ID: 2-s2.0-85075463168OAI: oai:DiVA.org:kth-263307DiVA, id: diva2:1368041
Note

QC 20191106. QC 20200110

Available from: 2019-11-05 Created: 2019-11-05 Last updated: 2020-03-09Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Hsieh, Yves S. Y.

Search in DiVA

By author/editor
Hsieh, Yves S. Y.
By organisation
Glycoscience
In the same journal
Carbohydrate Polymers
Pharmaceutical SciencesAnalytical ChemistryGeriatrics

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 116 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf