Phase Equilibria and Thermodynamics of p-Hydroxybenzoic acid
2006 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 95, no 4, 748-760 p.Article in journal (Refereed) Published
The prevalence of phases and associated solubilities of p-hydroxybenzoic acid have been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate at temperatures from 10 to 50 degrees C. Thermodynamic data was acquired through determination of van't Hoff enthalpy of solution, enthalpy of fusion, and melting temperature. Indications of polymorphic enantiotropy were found primarily through solubility analysis and FTIR-ATR. A comprehensive thermodynamic investigation disclosed correlation between the van't Hoff enthalpy of solution and the solubility in different solvents. A higher solubility is linked to a lower van't Hoff enthalpy of solution. A thermodynamic analysis to discriminate between different solid phases is presented.
Place, publisher, year, edition, pages
2006. Vol. 95, no 4, 748-760 p.
p-hydroxybenzoic acid, 4-hydroxybenzoic acid, polymorphism, pseudopolymorphism, solvate, complexation, solubility, desolvation, solid state stability, van't Hoff
IdentifiersURN: urn:nbn:se:kth:diva-8414DOI: 10.1002/jps.20569ISI: 000236485300004ScopusID: 2-s2.0-33645991201OAI: oai:DiVA.org:kth-8414DiVA: diva2:13728
QC 201008312008-05-122008-05-122010-12-17Bibliographically approved