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CryoEM: a crystals to single particles round-trip
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Structural Biotechnology.ORCID iD: 0000-0002-3220-9402
2019 (English)In: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 58, p. 59-67Article in journal (Refereed) Published
Abstract [en]

In the era of intense and steadily increasing attention to cryo electron microscopy (cryoEM) as a powerful tool in structural biology, particularly with regard to randomly oriented biological macromolecules, studies of 2D and small 3D crystals using cryoEM provide added value for addressing-specific questions. Size and shape demands are not as restrictive as for single particle specimens. Crystallization may stabilize whole or partly flexible molecules. Resolutions beyond 2 A, for 3D crystals even sub-angstrom ngstrom structures, can be obtained allowing studies of chemical properties in detail. The electron dose can be kept low and reduce radiation damage for sensitive specimens. In contrast to X-ray crystallography, scattering of electrons will be directly related to the Coulomb potential and thus give information about charge distribution in biomolecules.

Place, publisher, year, edition, pages
CURRENT BIOLOGY LTD , 2019. Vol. 58, p. 59-67
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Biological Sciences
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URN: urn:nbn:se:kth:diva-264312DOI: 10.1016/j.sbi.2019.05.008ISI: 000494891800011PubMedID: 31233976Scopus ID: 2-s2.0-85067405242OAI: oai:DiVA.org:kth-264312DiVA, id: diva2:1374599
Note

QC 20191202

Available from: 2019-12-02 Created: 2019-12-02 Last updated: 2020-01-08Bibliographically approved

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Hebert, Hans

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