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Systems biology perspective for studying the gut microbiota in human physiology and liver diseases
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2851-9651
Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden..
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-4858-8056
Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Gothenburg, Sweden..ORCID iD: 0000-0003-0786-8091
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2019 (English)In: EBioMedicine, E-ISSN 2352-3964, Vol. 49, p. 364-373Article, review/survey (Refereed) Published
Abstract [en]

The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.

Place, publisher, year, edition, pages
ELSEVIER , 2019. Vol. 49, p. 364-373
Keywords [en]
Gut microbiome, Liver diseases, Host-microbiome interactions, Systems biology, Personalized medicine, Meta-omics, Biomarker, Metabolic models
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:kth:diva-265189DOI: 10.1016/j.ebiom.2019.09.057ISI: 000497363700043PubMedID: 31636011Scopus ID: 2-s2.0-85073823469OAI: oai:DiVA.org:kth-265189DiVA, id: diva2:1380764
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20191219

Available from: 2019-12-19 Created: 2019-12-19 Last updated: 2020-06-05Bibliographically approved

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Altay, ÖzlemUhlén, MathiasMardinoglu, Adil

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