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Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice
Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.;Yale Sch Med, Dept Comparat Med, New Haven, CT USA..
Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland..ORCID iD: 0000-0001-5762-6010
Univ Pavia, Dept Publ Hlth Expt & Forens Med, Pavia, Italy..
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2019 (English)In: NATURE METABOLISM, ISSN 2522-5812, Vol. 1, no 8, p. 830-843Article in journal (Refereed) Published
Abstract [en]

Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of 'physiologically humanized' mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 degrees C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular characteristics (both marker and adipose-selective gene expression) of classical brown fat, but not of brite/beige fat, of these physiologically humanized mice are notably similar to human BAT. We also demonstrate, both in silico and experimentally, that in physiologically humanized mice only classical BAT possesses a high thermogenic potential. These observations suggest that classical rodent BAT is the tissue of choice for translational studies aimed at recruiting human BAT to counteract the development of obesity and its comorbidities.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 1, no 8, p. 830-843
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Biological Sciences
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URN: urn:nbn:se:kth:diva-266323DOI: 10.1038/s42255-019-0101-4ISI: 000500745300010OAI: oai:DiVA.org:kth-266323DiVA, id: diva2:1382930
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QC 20200107

Available from: 2020-01-07 Created: 2020-01-07 Last updated: 2020-01-07Bibliographically approved

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CiteExportLink to record
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