Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia
Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2261-0881
Karolinska Inst, Karolinska Univ Hosp, BioClin, Cardiovasc Med Unit,Dept Med,Ctr Mol Med, Stockholm, Sweden..
Sahlgrens Univ Hosp, Dept Clin Physiol, Gothenburg, Sweden..
Show others and affiliations
2019 (English)In: Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, E-ISSN 1095-8584, Vol. 137, p. 1-8Article in journal (Refereed) Published
Abstract [en]

Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 137, p. 1-8
Keywords [en]
MTTP, Polymorphism, Heart, Expression, Function
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-266435DOI: 10.1016/j.yjmcc.2019.09.003ISI: 000502686600001PubMedID: 31533023Scopus ID: 2-s2.0-85073149921OAI: oai:DiVA.org:kth-266435DiVA, id: diva2:1385676
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20200115

Available from: 2020-01-15 Created: 2020-01-15 Last updated: 2020-02-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Arif, MuhammadMardinoglu, Adil

Search in DiVA

By author/editor
Arif, MuhammadMardinoglu, Adil
By organisation
Systems BiologyScience for Life Laboratory, SciLifeLab
In the same journal
Journal of Molecular and Cellular Cardiology
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 36 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf