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Influence of Biocorona Formation on the Transformation and Dissolution of Cobalt Nanoparticles under Physiological Conditions
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Surface and Corrosion Science.ORCID iD: 0000-0001-7744-0811
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Surface and Corrosion Science.ORCID iD: 0000-0003-2100-8864
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Surface and Corrosion Science.ORCID iD: 0000-0003-2206-0082
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Surface and Corrosion Science. Division Bioscience and Materials, RISE Research Institutes of Sweden, Stockholm, 111 21, Sweden.ORCID iD: 0000-0001-7496-1101
2019 (English)In: ACS Omega, ISSN 2470-1343, Vol. 4, no 26, p. 21778-21791Article in journal (Refereed) Published
Abstract [en]

Cobalt (Co) nanoparticles (NPs) are produced in different applications and unintentionally generated at several occupational and traffic settings. Their diffuse dispersion may lead to interactions with humans and aquatic organisms via different exposure routes that include their transformation/dissolution in biological media. This paper has investigated the particle stability and reactivity of Co NPs (dispersed by sonication prior to exposure) interacting with selected individual biomolecules (amino acids, polypeptides, and proteins) in phosphate-buffered saline (PBS). No or minor adsorption of amino acids (glutamine, glutamic acid, lysine, and cysteine) was observed on the Co NPs, independent of the functional group and charge. Instead, phosphate adsorption resulted in the formation of a surface layer (a corona) of Co phosphate. The adsorption of larger biomolecules (polyglutamic acid, polylysine, lysozyme, and mucin) was evident in parallel with the formation of Co phosphate. The dissolution of the Co NPs was rapid as 35-55% of the particle mass was dissolved within the first hour of exposure. The larger biomolecules suppressed the dissolution initially compared to exposure in PBS only, whereas the dissolution was essentially unaffected by the presence of amino acids, with cysteine as an exception. The formation of Co phosphate on the NP surface reduced the protective properties of the surface oxide of the Co NPs, as seen from the increased levels of the released Co when compared with the nonphosphate-containing saline. The results underline the diversity of possible outcomes with respect to surface characteristics and dissolution of Co NPs in biological media and emphasize the importance of surface interactions with phosphate on the NP characteristics and reactivity.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019. Vol. 4, no 26, p. 21778-21791
National Category
Chemical Sciences
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URN: urn:nbn:se:kth:diva-266719DOI: 10.1021/acsomega.9b02641ISI: 000504635000015PubMedID: 31891055Scopus ID: 2-s2.0-85076772366OAI: oai:DiVA.org:kth-266719DiVA, id: diva2:1386452
Note

QC 20200117

Available from: 2020-01-17 Created: 2020-01-17 Last updated: 2020-02-04Bibliographically approved

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Mei, NanxuanOdnevall Wallinder, IngerBlomberg, Eva

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