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Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Polymer Technology. KTH, School of Engineering Sciences (SCI), Engineering Mechanics, Vehicle Engineering and Solid Mechanics, Solid Mechanics.ORCID iD: 0000-0003-1402-273X
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-6877-7858
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-1922-128X
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2020 (English)In: Materials & design, ISSN 0264-1275, E-ISSN 1873-4197, Vol. 188, article id 108488Article in journal (Refereed) Published
Abstract [en]

Degradable porous polymeric structures are attractive candidates for biological tissue scaffolds, and adequate mechanical, transport, chemical and biological properties determine their functionality. Aside from the properties of polymer-based materials, the scaffold's meso-structure controls its elasticity at the organ length-scale. This study investigated the effect of the meso-structure on scaffolds' mechanical and transport properties using finite element analysis (FEA) and computational fluid dynamics (CFD). A number of poly (ε-caprolactone) (PCL) - based scaffolds were 3D printed, analyzed by microcomputed tomography (micro-CT) and mechanically tested. We found that the gradient (G) and gradient and staggered (GS) meso-structure designs led to a higher scaffold permeability, a more homogeneous flow inside the scaffold, and a lower wall shear stress (WSS) in comparison with the basic (B) meso-structure design. The GS design resulted in scaffold stiffness as low as 1.07/0.97 MPa under compression/tension, figures that are comparative with several soft tissues. Image processing of micro-CT data demonstrated that the imposed meso-structures could have been adequately realized through 3D printing, and experimental testing validated FEA analysis. Our results suggest that the properties of 3D-printed PCL-based scaffolds can be tuned via meso-structures toward soft tissue engineering applications. The biological function of designed scaffolds should be further explored in-situ studies.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 188, article id 108488
Keywords [en]
3D printing, Computational fluid dynamics, Finite element analysis, Meso-structure, Scaffold, Soft tissue engineering
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-267795DOI: 10.1016/j.matdes.2020.108488ISI: 000514567900012Scopus ID: 2-s2.0-85077922391OAI: oai:DiVA.org:kth-267795DiVA, id: diva2:1394969
Note

QC 20200220

Available from: 2020-02-20 Created: 2020-02-20 Last updated: 2020-04-24Bibliographically approved

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Liu, HailongAhlinder, AstridFinne Wistrand, AnnaGasser, T. Christian

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