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Exploratory Full-Field Strain Analysis of Regenerated Bone Tissue from Osteoinductive Biomaterials.
KTH, School of Engineering Sciences (SCI), Engineering Mechanics, Vehicle Engineering and Solid Mechanics, Biomechanics. Zeiss Global Centre, School of Mechanical and Design Engineering, University of Portsmouth, Portsmouth, PO1 3DJ, UK.ORCID iD: 0000-0002-3534-8838
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2020 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 13, no 1, article id E168Article in journal (Refereed) Published
Abstract [en]

Biomaterials for bone regeneration are constantly under development, and their application in critical-sized defects represents a promising alternative to bone grafting techniques. However, the ability of all these materials to produce bone mechanically comparable with the native tissue remains unclear. This study aims to explore the full-field strain evolution in newly formed bone tissue produced in vivo by different osteoinductive strategies, including delivery systems for BMP-2 release. In situ high-resolution X-ray micro-computed tomography (microCT) and digital volume correlation (DVC) were used to qualitatively assess the micromechanics of regenerated bone tissue. Local strain in the tissue was evaluated in relation to the different bone morphometry and mineralization for specimens (n = 2 p/treatment) retrieved at a single time point (10 weeks in vivo). Results indicated a variety of load-transfer ability for the different treatments, highlighting the mechanical adaptation of bone structure in the early stages of bone healing. Although exploratory due to the limited sample size, the findings and analysis reported herein suggest how the combination of microCT and DVC can provide enhanced understanding of the micromechanics of newly formed bone produced in vivo, with the potential to inform further development of novel bone regeneration approaches.

Place, publisher, year, edition, pages
2020. Vol. 13, no 1, article id E168
Keywords [en]
biomaterials, bone regeneration, digital volume correlation, in situ mechanics, microCT
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-268995DOI: 10.3390/ma13010168PubMedID: 31906343Scopus ID: 2-s2.0-85079793652OAI: oai:DiVA.org:kth-268995DiVA, id: diva2:1403058
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2020-05-11

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