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Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates
KTH, School of Biotechnology (BIO), Industrial Biotechnology. (AlbaNova University Center)
KTH, School of Biotechnology (BIO), Biochemistry (closed 20130101).
2020 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 362, no 5, p. 1156-1166Article in journal (Refereed) Published
Abstract [en]

Abstract The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl-tert-butylether), a non-ionic surfactant and a minimal amount of water. In these conditions, amine transaminases (ATA) were shown to efficiently carry out the reductive amination of variously substituted cyclohexanones, providing good conversions often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized through biocatalysis, analyzed and stereochemically characterized.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2020. Vol. 362, no 5, p. 1156-1166
Keywords [en]
biotransformations, amination, multiphase catalysis, enzyme catalysis, diastereoselectivity, chemoenzymatic synthesis
National Category
Biocatalysis and Enzyme Technology
Research subject
Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-269562DOI: 10.1002/adsc.201901434Scopus ID: 2-s2.0-85078666403OAI: oai:DiVA.org:kth-269562DiVA, id: diva2:1413197
Funder
EU, FP7, Seventh Framework ProgrammeAvailable from: 2020-03-09 Created: 2020-03-09 Last updated: 2020-05-11

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Berglund, PerSvedendahl Humble, Maria
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Industrial BiotechnologyBiochemistry (closed 20130101)
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