Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Printability and critical insight into polymer properties during direct- extrusion based 3D printing of medical grade polylactide and copolyesters
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.
Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Norway, Årstadveien 19, 5009 Bergen, Norway.
Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Norway, Årstadveien 19, 5009 Bergen, Norway.
Show others and affiliations
2019 (English)In: BiomacromoleculesArticle in journal (Refereed) Published
Abstract [en]

Various 3D printing techniques currently usedegradable polymers such as aliphatic polyesters to create welldefinedscaffolds. Even though degradable polymers are influencedby the printing process, and this subsequently affects themechanical properties and degradation profile, degradation of thepolymer during the process is not often considered. Degradablescaffolds are today printed and cell−material interactions evaluatedwithout considering the fact that the polymer change while printingthe scaffold. Our methodology herein was to vary the printingparameters such as temperature, pressure, and speed to define therelationship between printability, polymer microstructure, composition,degradation profile during the process, and rheologicalbehavior. We used high molecular weight medical-grade (co)polymers, poly(L-lactide-co-ε-caprolactone) (PCLA), poly(Llactide-co-glycolide) (PLGA), and poly(D,L-lactide-co-glycolide) (PDLGA), with L-lactide content ranging from 25 to 100 mol%, for printing in an extrusion-based printer (3D Bioplotter). Optical microscopy confirmed that the polymers were printable athigh resolution and good speed, until a certain degree of degradation. The results show also that printability can not be claimedjust by optimizing printing parameters and highlight the importance of a careful analysis of how the polymer’s structure andproperties vary during printing. The polymers thermally decomposed from the first processing minute and caused a decrease inthe average block length of the lactide blocks in the copolymers and generated lower crystallinity. Poly(L-lactide) (PLLA) andPCLA are printable at a higher molecular weight, less degradation before printing was possible, compared to PLGA andPDLGA, a result explained by the higher complex viscosity and more elastic polymeric melt of the copolymer containingglycolide (GA) and lactide (LA). In more detail, copolymers comprised of LA and ε-caprolactone (CL) formed lower molecularweight compounds over the course of printing, while the PLGA copolymer was more susceptible to intermoleculartransesterification reactions, which do not affect the overall molecular weight, but cause changes in the copolymermicrostructure. This results in a longer printing time for PLGA than PLLA and PCLA

Place, publisher, year, edition, pages
2019.
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-268326DOI: 10.1021/acs.biomac.9b01112PubMedID: 31566357Scopus ID: 2-s2.0-85073450017OAI: oai:DiVA.org:kth-268326DiVA, id: diva2:1413347
Note

QC 20200310

Available from: 2020-03-10 Created: 2020-03-10 Last updated: 2020-05-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopushttps://pubs.acs.org/doi/10.1021/acs.biomac.9b01112

Authority records BETA

Jain, ShubhamFuoco, TizianaFinne Wistrand, Anna

Search in DiVA

By author/editor
Jain, ShubhamFuoco, TizianaFinne Wistrand, Anna
By organisation
Fibre- and Polymer TechnologyFibre and Polymer Technology
Polymer Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 5 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf