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Health effects of arsenic exposure in Latin America: An overview of the past eight years of research
Indiana Univ, Dept Environm & Occupat Hlth, Sch Publ Hlth, Bloomington, IN USA..ORCID iD: 0000-0001-5513-0337
Indiana Univ, Dept Environm & Occupat Hlth, Sch Publ Hlth, Bloomington, IN USA..
Univ Southern Queensland, Sch Civil Engn & Surveying, West St, Toowoomba, Qld 4350, Australia.;Univ Southern Queensland, UNESCO Chair Groundwater Arsen Agenda Sustainable, West St, Toowoomba, Qld 4350, Australia..
KTH, School of Architecture and the Built Environment (ABE), Sustainable development, Environmental science and Engineering, Water and Environmental Engineering.ORCID iD: 0000-0003-4350-9950
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2020 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 710, article id 136071Article in journal (Refereed) Published
Abstract [en]

Studies conducted over the past eight years in Latin America (IA) have continued to produce new knowledge regarding health impacts of arsenic (As) in drinking water. We conducted a systematic review of 92 peer-reviewed English articles published between 2011 and 2018 to expand our understanding on these health effects. Majority of the LA studies on As have been conducted in Chile and Mexico. Additional data have emerged from As-exposed populations in Argentina, Bolivia, Brazil, Colombia, Ecuador, and Uruguay. The present review has documented recent data on the biomarkers of As exposure, genetic susceptibility and genotoxicity, and risk assessment to further characterize the health effects and exposed populations. Some recent findings on the associations of As with bladder and lung cancers, reproductive outcomes, and declined cognitive performance have been consistent with what we reported in our previous systematic review article. We have found highly convincing evidence of in utero As exposure as a significant risk factor for several health outcomes, particularly for bladder cancer, even at moderate level. New data have emerged regarding the associations of As with breast and laryngeal cancers as well as type 2 diabetes. We observed early life As exposure to be associated with kidney injury, carotid intima-media thickness, and various pulmonary outcomes in children. Other childhood effects such as low birth weight, low gestational age, anemia, increased apoptosis, and decreased cognitive functions were also reported. Studies identified genetic variants of As methyltransferase that could determine susceptibility to As related health outcomes. Arsenic-induced DNA damage and alteration of gene and protein expression have been reported. While the scope of research is still vast, the substantial work done on As exposure and its health effects in LA will help direct further large-scale studies for more comprehensive knowledge and plan appropriate mitigation strategies.

Place, publisher, year, edition, pages
ELSEVIER , 2020. Vol. 710, article id 136071
Keywords [en]
Water arsenic, Latin America, Cancers, Cardiopulmonary outcomes, In utero and early life effects, Genetic susceptibility
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-269443DOI: 10.1016/j.scitotenv.2019.136071ISI: 000511088800065PubMedID: 31918184Scopus ID: 2-s2.0-85077322073OAI: oai:DiVA.org:kth-269443DiVA, id: diva2:1414765
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QC 20200316

Available from: 2020-03-16 Created: 2020-03-16 Last updated: 2020-03-16Bibliographically approved

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Bhattacharya, Prosun

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