Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden..
Acad Specialist Ctr, Ctr Rheumatol, Stockholm Hlth Serv, S-10235 Stockholm, Sweden..
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden..
Karolinska Inst, Dept Dent Med, Div Orofacial Diagnost & Surg Image & Funct Odont, S-14104 Huddinge, Sweden..
Show others and affiliations
2019 (English)In: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, no 5, article id 630Article in journal (Refereed) Published
Abstract [en]

This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.

Place, publisher, year, edition, pages
2019. Vol. 8, no 5, article id 630
Keywords [en]
rheumatoid arthritis, periodontitis, periodontal disease, anti-citrullinated protein autoantibodies, rheumatoid factor, smoking, medication, Porphyromonas gingivalis
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-270845DOI: 10.3390/jcm8050630ISI: 000470992500065PubMedID: 31072030OAI: oai:DiVA.org:kth-270845DiVA, id: diva2:1415074
Note

QC 20200317

Available from: 2020-03-17 Created: 2020-03-17 Last updated: 2020-03-17Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Hu, Yue O. O.Andersson, Anders F.

Search in DiVA

By author/editor
Hu, Yue O. O.Klinge, BjornAndersson, Anders F.
By organisation
School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH)Science for Life Laboratory, SciLifeLab
Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf