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Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden..
KTH, Centres, Science for Life Laboratory, SciLifeLab. Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden..ORCID iD: 0000-0002-9031-9562
KTH, Centres, Science for Life Laboratory, SciLifeLab. Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2970 Horsholm, Denmark..ORCID iD: 0000-0001-8993-048X
Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2970 Horsholm, Denmark.;Royal Inst Technol, Sci Life Lab, SE-17121 Stockholm, Sweden..ORCID iD: 0000-0002-9955-6003
2017 (English)In: npj Systems Biology and Applications, ISSN 2056-7189, Vol. 3, article id UNSP 22Article in journal (Refereed) Published
Abstract [en]

Protein secretory pathway in eukaryal cells is responsible for delivering functional secretory proteins. The dysfunction of this pathway causes a range of important human diseases from congenital disorders to cancer. Despite the piled-up knowledge on the molecular biology and biochemistry level, the tissue-specific expression of the secretory pathway genes has not been analyzed on the transcriptome level. Based on the recent RNA-sequencing studies, the largest fraction of tissue-specific transcriptome encodes for the secretome (secretory proteins). Here, the question arises that if the expression levels of the secretory pathway genes have a tissue-specific tuning. In this study, we tackled this question by performing a meta-analysis of the recently published transcriptome data on human tissues. As a result, we detected 68 as called "extreme genes" which show an unusual expression pattern in specific gene families of the secretory pathway. We also inspected the potential functional link between detected extreme genes and the corresponding tissues enriched secretome. As a result, the detected extreme genes showed correlation with the enrichment of the nature and number of specific post-translational modifications in each tissue's secretome. Our findings conciliate both the housekeeping and tissue-specific nature of the protein secretory pathway, which we attribute to a fine-tuned regulation of defined gene families to support the diversity of secreted proteins and their modifications.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 3, article id UNSP 22
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Biological Sciences
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URN: urn:nbn:se:kth:diva-271108DOI: 10.1038/s41540-017-0021-4ISI: 000459648000023PubMedID: 28845240Scopus ID: 2-s2.0-85037360733OAI: oai:DiVA.org:kth-271108DiVA, id: diva2:1415122
Note

QC 20200317

Available from: 2020-03-17 Created: 2020-03-17 Last updated: 2020-03-17Bibliographically approved

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Uhlén, Mathias

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