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An atlas of the protein-coding genes in the human, pig, and mouse brain
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science. Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden..ORCID iD: 0000-0002-0327-7377
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-7422-6104
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology.ORCID iD: 0000-0003-0198-7137
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-7000-4416
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2020 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 367, no 6482, p. 1090-+, article id eaay5947Article in journal (Refereed) Published
Abstract [en]

The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2020. Vol. 367, no 6482, p. 1090-+, article id eaay5947
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Medical Genetics
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URN: urn:nbn:se:kth:diva-271745DOI: 10.1126/science.aay5947ISI: 000520018400034PubMedID: 32054698Scopus ID: 2-s2.0-85081532587OAI: oai:DiVA.org:kth-271745DiVA, id: diva2:1422585
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QC 20200408

Available from: 2020-04-08 Created: 2020-04-08 Last updated: 2020-04-08Bibliographically approved

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Sjöstedt, EvelinaZhong, WenFagerberg, LinnKarlsson, MaxOksvold, PerEdfors, FredrikMardinoglu, AdilZhang, Chengvon Feilitzen, KalleUhlén, Mathias

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Sjöstedt, EvelinaZhong, WenFagerberg, LinnKarlsson, MaxOksvold, PerEdfors, FredrikHikmet, FeriaXu, XunMardinoglu, AdilZhang, Chengvon Feilitzen, KalleLuo, YonglunUhlén, Mathias
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