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Crystal Growth Kinetics of a Metastable Polymorph of Tolbutamide in Organic Solvents
Univ Limerick, Dept Chem & Environm Sci, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Limerick V94 T9PX, Ireland..
Univ Limerick, Dept Chem & Environm Sci, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Limerick V94 T9PX, Ireland..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemical Engineering. Univ Limerick, Dept Chem & Environm Sci, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Limerick V94 T9PX, Ireland.;.
2020 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 20, no 3, p. 1985-1996Article in journal (Refereed) Published
Abstract [en]

The crystal growth of tolbutamide (Form I-L) in different solvents has been investigated by isothermal seeded desupersaturation experiments at different temperatures (268-283 K). Experimental data have been evaluated using empirical power law equations and the mechanistic based models: Burton-Cabrera-Frank (BCF) and birth and spread (B + S). The estimated activation energies and growth exponents suggest surface integration controlled growth as confirmed separately by mass transfer analysis. From the B + S model, the estimated solid-liquid interfacial energies and the mean diffusion distances on the surface range are 1.23-1.90 mJ/m(2) and 1-16 nm, respectively. The growth rate is strongly dependent on the solvent, decreasing in the order: acetonitrile > ethanol > ethyl acetate > n-propanol > toluene. The crystal growth becomes slower as the overall strength of the solute-solvent binding increases. This influence of the solvent corresponds very well with that found for nucleation of tolbutamide in the same solvents and further supports the hypothesis that desolvation is an important step in crystallization. The similarity in the influence of the solvent on the kinetics of nucleation and growth very strongly supports the hypothesis that the solvent-solute interactions play an important role in the kinetics of formation of crystalline phases.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2020. Vol. 20, no 3, p. 1985-1996
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Chemical Engineering
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URN: urn:nbn:se:kth:diva-271938DOI: 10.1021/acs.cgd.9b01637ISI: 000518701900069Scopus ID: 2-s2.0-85081154939OAI: oai:DiVA.org:kth-271938DiVA, id: diva2:1424820
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QC 20200420

Available from: 2020-04-20 Created: 2020-04-20 Last updated: 2020-04-20Bibliographically approved

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