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Molecular processes in an electrochemical clozapine sensor
KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Micro and Nanosystems. Univ Maryland, MSAL, Syst Res Inst, Dept Elect & Comp Engn, College Pk, MD 20742 USA.;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.ORCID iD: 0000-0002-2331-4833
Univ Maryland, MSAL, Syst Res Inst, Dept Elect & Comp Engn, College Pk, MD 20742 USA.;US Navy Naval Air Syst Command, Fleet Readiness Ctr East, Cherry Point, NC 28533 USA..
Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA..
Univ Maryland, MSAL, Syst Res Inst, Dept Elect & Comp Engn, College Pk, MD 20742 USA.;Ben Gurion Univ Negev, Dept Biomed Engn, IL-8410501 Beer Sheva, Israel..ORCID iD: 0000-0002-6237-0440
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2017 (English)In: Biointerphases, ISSN 1934-8630, E-ISSN 1559-4106, Vol. 12, no 2, article id 02B401Article in journal (Refereed) Published
Abstract [en]

Selectivity presents a crucial challenge in direct electrochemical sensing. One example is schizophrenia treatment monitoring of the redox-active antipsychotic clozapine. To accurately assess efficacy, differentiation from its metabolite norclozapine-similar in structure and redox potentialis critical. Here, the authors leverage biomaterials integration to study, and effect changes in, diffusion and electron transfer kinetics of these compounds. Specifically, the authors employ a catechol-modified chitosan film, which the authors have previously presented as the first electrochemical detection mechanism capable of quantifying clozapine directly in clinical serum. A key finding in our present work is differing dynamics between clozapine and norclozapine once the authors interface the electrodes with chitosan-based biomaterial films. These additional dimensions of redox information can thus enable selective sensing of largely analogous small molecules. 

Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2017. Vol. 12, no 2, article id 02B401
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Biophysics
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URN: urn:nbn:se:kth:diva-271574DOI: 10.1116/1.4982709ISI: 000400683300002PubMedID: 28460529Scopus ID: 2-s2.0-85019004994OAI: oai:DiVA.org:kth-271574DiVA, id: diva2:1425806
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QC 20200422

Available from: 2020-04-22 Created: 2020-04-22 Last updated: 2020-04-22Bibliographically approved

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Winkler, Thomas

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