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Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis
Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.;Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden..
Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden..
Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden..
Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden..ORCID iD: 0000-0002-5513-8221
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2020 (English)In: Frontiers in Cell and Developmental Biology, ISSN 2296-634X, Vol. 8, article id 122Article in journal (Refereed) Published
Abstract [en]

A joint connects two or more bones together to form a functional unit that allows different types of bending and movement. Little is known about how the opposing ends of the connected bones are developed. Here, applying various lineage tracing strategies we demonstrate that progenies of Gdf5-, Col2-, Prrx1-, and Gli1-positive cells contribute to the growing epiphyseal cartilage in a spatially asymmetrical manner. In addition, we reveal that cells in the cartilaginous anlagen are likely to be the major sources for epiphyseal cartilage. Moreover, Gli1-positive cells are found to proliferate along the skeletal edges toward the periarticular region of epiphyseal surface. Finally, a switch in the mechanism of growth from cell division to cell influx likely occurs in the epiphyseal cartilage when joint cavitation has completed. Altogether, our findings reveal an asymmetrical mechanism of growth that drives the formation of epiphyseal cartilage ends, which might implicate on how the articular surface of these skeletal elements acquires their unique and sophisticated shape during embryonic development.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2020. Vol. 8, article id 122
Keywords [en]
joint, cartilage, clonal tracing, asymmetrical, dynamics, embryonic development
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-272806DOI: 10.3389/fcell.2020.00122ISI: 000525115900001PubMedID: 32211405Scopus ID: 2-s2.0-85082588142OAI: oai:DiVA.org:kth-272806DiVA, id: diva2:1427202
Note

QC 20200429

Available from: 2020-04-29 Created: 2020-04-29 Last updated: 2020-04-29Bibliographically approved

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Edwards, Steven

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