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Towards predictive simulation of single feed semibatch reaction crystallizationSimulation of single feed semibatch reaction crystallization processes
KTH, School of Chemical Science and Engineering (CHE).
KTH, School of Chemical Science and Engineering (CHE).
2009 (English)In: Chemical Engineering Science, ISSN 0009-2509, E-ISSN 1873-4405, Vol. 64, no 7, 1559-1576 p.Article in journal (Refereed) Published
Abstract [en]

A population balance model is developed over single-feed semi-batch reaction crystallization of benzoic acid. The model is evaluated by comparison with experimental data, and simulations are carried out to advance the understanding of the process. The model accounts for chemical reaction micro and me, somixing, primary nucleation, crystal growth and growth rate dispersion (GRD). Two mechanistic mixing models are evaluated: the segregated feed model and the engulfment model (E-model) with mesomixing. When the mixing is described by the E-model (engulfment model) and GRD is accounted for, the model quite well captures the influence of reactant concentrations, agitation rate, feed point location, feed pipe diameter, total feeding time and crystallizer volume, on the product weight mean size. When using the SF-model (segregated feed model) the results are less satisfactory. The kinetics of nucleation and crystal growth have a great impact on the results of the simulations, influencing the product weight mean size as well as the response to changes in the processing conditions. A new set of kinetic data for benzoic acid derived from semi-batch experimental results are presented

Place, publisher, year, edition, pages
2009. Vol. 64, no 7, 1559-1576 p.
Keyword [en]
Precipitation, Mixing, Population balance, Scale-up, Kinetics, Benzoic acid, Batch
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-8876DOI: 10.1016/j.ces.2008.12.001ISI: 000264617200019Scopus ID: 2-s2.0-60549093358OAI: oai:DiVA.org:kth-8876DiVA: diva2:14348
Note
Uppdaterad från manuskript till artikel: 20100930 Tidigare titel: Simulation of single feed semibatch reaction crystallization processes QC 20100930Available from: 2005-12-05 Created: 2005-12-05 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Process modeling of semibatch reaction crystallization
Open this publication in new window or tab >>Process modeling of semibatch reaction crystallization
2005 (English)Doctoral thesis, comprehensive summary (Other scientific)
Abstract [en]

This thesis aims at increasing the fundamental understanding of reaction crystallization by modeling, simulations and parameter estimation. Benzoic acid is used as the model compound.

A population balance model of single-feed semi-batch reaction crystallization is developed, accounting for chemical reaction, mixing, nucleation, growth, and growth rate dispersion. The model is evaluated by comparing the results with data from previously published semi-batch experiments. Two different mechanistic mixing models are used to describe mixing: the engulfment model with mesomixing and the segregated feed model. When the engulfment mixing model is used, the semi-batch model correctly captures the variation in weight mean size with varying agitation rate, feed point location, reactant concentration, feed pipe diameter, and total feed time. However, at scaling-up, a decrease in weight mean size with increasing crystallizer volume is predicted, which is not found experimentally. When the segregated feed model is used to describe mixing, the results are unsatisfactory.

The crystallization kinetics have a great impact on the performance of the model, influencing both the final mean size, and the predicted influence of changes in the processing conditions. The kinetics of nucleation and growth are determined from T-mixer experiments. Three population balance models of increasing complexity are developed and used in parameter estimations by non-linear optimization. The T-mixer model accounts for nucleation, growth and growth rate dispersion. Five or six kinetic parameters are estimated using data from 14 experiments at 8 different initial supersaturation levels. Depending on the assumptions in the model, different kinetics are estimated. The main differences are found in the nucleation and growth rate constants. The T-mixer kinetics yields unsatisfactory results in the semi-batch simulations, with a predicted mean size that is significantly smaller than the experimental and a less pronounced influence of processing conditions that are related to mesomixing.

An attempt is made to model aging of benzoic acid precipitates formed at high supersaturation. A model of Ostwald ripening gives a reasonably good description of the changes in the size distribution, provided that the observed shape change during aging is accounted for. However, significant deviations remain, in particular, the broadening of the aged size distribution is more pronounced in the experiments than in the simulations. There are indications that the observed aging might be caused by kinetic ripening, driven by a transformation to a more regular shape or a less strained crystal, rather than by Ostwald ripening.

Place, publisher, year, edition, pages
Stockholm: KTH, 2005. x, 67 p.
Series
Trita-KET, ISSN 1104-3466 ; 223
Keyword
Reaction crystallization, benzoic acid, nucleation, growth, kinetics, growth rate dispersion
National Category
Atom and Molecular Physics and Optics
Identifiers
urn:nbn:se:kth:diva-538 (URN)91-7178-212-5 (ISBN)
Public defence
2005-12-12, F3, Lindstedtsvägen 26, Stockholm, 13:00
Opponent
Supervisors
Note
QC 20100930Available from: 2005-12-05 Created: 2005-12-05 Last updated: 2010-09-30Bibliographically approved

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