Under new scenarios with high shares of variable renewable electricity, combined cycle gas turbines (CCGT) are required to improve their flexibility, in terms of ramping capabilities and part-load efficiency, to help balance the power system. Simultaneously, liberalization of electricity markets and the complexity of its hourly price dynamics are affecting the CCGT profitability, leading the need for optimizing its operation. Among the different possibilities to enhance the power plant performance, an inlet air conditioning unit (ICU) offers the benefit of power augmentation and “minimum environmental load” (MEL) reduction by controlling the gas turbine inlet temperature using cold thermal energy storage and a heat pump. Consequently, an evaluation of a CCGT integrated with this inlet conditioning unit including a day-ahead optimized operation strategy was developed in this study.