Based on the analysis of the characteristics and operation status of the process industry, as well as the development of the global intelligent manufacturing industry, a new mode of intelligent manufacturing for the process industry, namely, deep integration of industrial artificial intelligence and the Industrial Internet with the process industry, is proposed. This paper analyzes the development status of the exist-ing three-tier structure of the process industry, which consists of the enterprise resource planning, the manufacturing execution system, and the process control system, and examines the decision-making, control, and operation management adopted by process enterprises. Based on this analysis, it then describes the meaning of an intelligent manufacturing framework and presents a vision of an intelligent optimal decision-making system based on human-machine cooperation and an intelligent autonomous control system. Finally, this paper analyzes the scientific challenges and key technologies that are crucial for the successful deployment of intelligent manufacturing in the process industry.